Whether the young friends of the post-80s and post-90s generation listen more and more frequently to their friends or classmates talk about the emergency of stroke for the elderly at home, and whether the dangerous condition is always worrying. This is also a reality that young friends have to face. As they grow older, their parents are gradually getting older. Cardiovascular health is the most severe test that parents have to face. You and your parents must be alert to the high incidence and harmfulness of cardiovascular diseases in the elderly.



Before the introduction of lipoprotein related phospholipase A2 (hereinafter referred to as phospholipase A2), it is necessary to know what cardiovascular events are seriously harmful to health? The most direct and core event is the occurrence of atherosclerosis. In atherosclerotic events, from plaque formation to plaque rupture, and then thrombosis, a series of serious cardiovascular events such as stroke, cerebral infarction, myocardial infarction, angina pectoris are finally triggered. So what kind of disease is atherosclerosis, what is the mechanism leading to its occurrence, and what role does phospholipase A2 play in it?



Atherosclerosis is one of the most common and important vascular diseases called arteriosclerosis. It is characterized by thickening and hardening of the arterial wall, loss of elasticity and narrowing of the lumen. Because the lipid accumulated on the arterial intima has a yellow appearance, it is called atherosclerosis. Hyperlipidemia, hypertension, smoking, diabetes and obesity are risk factors of atherosclerosis. It is precisely because of the persistence of these risk factors that atherosclerosis is induced. Up to now, the exact mechanism of atherosclerosis has not been fully clarified. In recent years, it has been generally believed that atherosclerosis is a chronic inflammatory disease, and a variety of risk factors lead to vascular endothelial dysfunction (the initiator of inflammation), and then lipid oxidation, foam cell formation (the key link of atherosclerosis), cytokines, inflammatory mediators The proliferation and migration of biological enzymes and smooth muscle cells lead to further inflammation and atherosclerosis.



What role does phospholipase A2 play in atherosclerosis? Now let's briefly introduce ourselves to lipoprotein related phospholipase A2:





My full name is lipoprotein associated phospholipase A2, and my English name is Lp PLA2. I am synthesized and secreted from mature macrophages and lymphocytes. It is a specific marker of vascular inflammation and is not affected by inflammation in other parts. Most of me are with low density lipoprotein (LDL). My work is to hydrolyze phospholipids on ox-LDL-C to produce proinflammatory substances lyso PC and ox-FA, thereby promoting inflammation and atherosclerosis. Therefore, I can dynamically monitor the degree of inflammation and stability of atherosclerotic plaque. When the degree of inflammation is high, my content will increase; When plaque is unstable, my content will also increase. Through me, we can predict the advanced predictive indicators of atherosclerosis related secondary cardiovascular diseases. Please pay attention to me, don't neglect me!



Through the introduction of phospholipase A2, you can understand that it is actually a key participant in atherosclerosis events. Don't ignore its content. Before you know your vascular disease through imaging, it is a dynamic indicator with strong specificity that can reflect your cardiovascular inflammatory process.